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Yul Brynner
Last Reset: 03:05, 14 May 06
Planta Med. 2006 May 29; [Epub ahead of print]
Palmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice.
Gonzalez-Trujano ME, Martinez AL, Reyes-Ramirez A, Reyes-Trejo B, Navarrete A.
Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatria, San Lorenzo Huipulco, Mexico D.F., Mexico.
The aim of this study was to investigate the behavioral effects of palmitone in the anti-anxiety response in experimental models in mice.
In the elevated plus-maze test, palmitone (0.3, 1, 3, 10 and 30 mg/kg, I. P.) lengthened, from 50 % to 199 %, the time spent in the open arm region of the maze at all doses tested, as compared to the vehicle group ( P < 0.001). In relation to the rearing activity in the exploratory cylinder, palmitone significantly modified ( P < 0.05), in a dose-dependent manner, this activity by decreasing the number of rearings with an effective dose value (ED (50)) and 95 % confidence limits (CL (50)) of 0.79 (0.23 - 2.68) mg/kg. In addition, in the hole-board test, nose-poking was also significantly decreased ( P < 0.01) in a dose-dependent fashion [ED (50) (CL (50)) = 9.07 (4.51 - 18.26) mg/kg].
Moreover, palmitone at any dose caused no change in motor activity nor disruption in traction performance. In contrast, diazepam, used as reference drug, produced an anxiolytic effect with a significant and dose-dependent decrease in motor coordination accompanied by disruption of the traction performance.
Behavioral studies suggest an anti-anxiety effect produced by palmitone, but its neuropharmacological profile differs from that observed for benzodiazepines such as diazepam.
PMID: 16732521 [PubMed - as supplied by publisher]
(Text has been reformatted for clarity; Ed.)
posted Saturday, 3 June 2006
tags: palmitone anxiety disorder