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Dianette acne treatment/oral contraceptive linked to depression

« H E » email
posted Tuesday, 9 May 2006

Dianette Acne Treatment/Oral Contraceptive Linked To Depression

The British Medicines and Healthcare products Regulatory Agency (MHRA) is reportedly carrying out a review of Dianette (also known as Diane 35) and the link to depression. Dianette contains two active ingredients, cyproterone acetate (an anti-androgenic progestogen) and ethinylestradiol (a synthetic estrogen).

The UK charity APRIL (Adverse Psychiatric Reactions Information Link) has compiled a dossier of reports from over 100 women who say that they suffered from severe depression whilst on the drug. Some have been taking Dianette for longer than is recommended and others have been prescribed antidepressants but were not advised by their GPs that the depression could have been exacerbated by the use of Dianette.

According to the report, the MHRA is particularly concerned by evidence that doctors are prescribing Dianette as a contraceptive in spite of warnings. In an email to Ms Kieve, who runs the charity, Jane Woolley of the pharmacovigilance risk assessment group said: "The MHRA shares your concerns over the prescribing of Dianette solely for contraception and has taken several steps in recent years to try to minimise this....The Patient Information Leaflet currently warns women with a present or past history of severe depressive state that their condition will need to be carefully monitored on Dianette and that depressive moods can sometimes occur in the first few months after starting Dianette. However we will be reviewing all the available data with respect to the development of psychiatric reactions in association with Dianette use. Any action that we take will therefore depend on the outcome of this review. In the meantime I would urge you to encourage the women/girls who contact you to either ask their doctors to report their symptoms to the MHRA or to report them directly through the yellow card system."

According to the BBC, the MHRA issued a statement which said: "Depression is a known side effect of Dianette and the product information contains warnings on this issue. The description of psychiatric reactions in the product information for healthcare professionals and patients is currently being reviewed by the MHRA. The product information (including the Patient Information Leaflet) will be updated if necessary. Patients who have concerns about Dianette should discuss the matter with their pharmacist or doctor at a routine appointment."

A spokesperson from Schering, who manufacture Dianette, said that: "Severe depression is listed in the patient information leaflet as a reason for stopping Dianette immediately. Depressive moods are also listed as a possible side effect. Dianette has been used internationally since 1985, and there is therefore 50 million treatment years of experience of use of the product globally. We share relevant data with the MHRA and patient safety is obviously of paramount concern."

APRIL has information on how oral contraceptives may trigger depression and what can be done to moderate this effect.

tags: cyproterone acetate            diane 35  

links: digg this    del.icio.us    technorati    reddit




1. Mel left...
Monday, 11 September 2006 4:45 pm

I have been on dianette for nearly a year and have been suffering from depression, anxiety and paranoia. i am so glad to read that this is a common side effect and have now been taken off it. I am shocked that I wasn't warned about this


2. CA left...
Monday, 22 January 2007 9:56 pm

I have been on Dianette for the past few months and I have suffered from depression paranoia and had panic attacks quite frequently! I have seen alot of negitive reports on dianette and am quite concerned that women are not warned that this can happen! I have now stoped taking dianette and since been feeling better, I realise its effects can however take a while to get out of your system.


3. Sonia left...
Wednesday, 24 January 2007 9:55 pm

Dianette made me very depressed. I have definitely felt better since I came off it and wouldn't recommend it to anyone.


4. Caroline left...
Wednesday, 21 February 2007 11:09 pm

I was on Dianette for 6 yrs and recently came off it as my sister was diagnosed with breast cancer so I was concerned about the estrogen content, I have a history of depression(past 9 yrs) and definitely feel my mood is better since coming off it. I was aware of the warning that is in the pack but as far as I was concerned Schering were covering ALL possible side effects and also their own backs by doing so.


5. Katrina left...
Saturday, 28 April 2007 2:17 pm

Yep, I developed anxiety and got panic attacks whilst on Dianne 35 ED from 2000-2004. Looking back at it, the anxiety started shortly after starting it. Same doctor who wrote the prescription for Dianne 35 ED (which i requested due to hirsuitism&painful periods) prescribed Ativan. Took Ativan for about a month but it left me feeling so unhuman, zombie and unfeeling that I went off it prefering the anxiety. I developed severe nocturnal asthma and allergies also.. I think it's got to do with vitamin B6 deficiency induced by Dianne, probably Ativan, probably the corticosteroids and ventolin I was taking for the asthma, probably the anti-histamines and decongestants I was continuously taking for the allergies, probably the glandular fever I had in 1999 prior to Dianne, and aggrevated by acute stressful periods, such as HSC, family leaving permanently to live overseas and getting married.


6. RL left...
Sunday, 27 January 2008 1:27 pm

I'm now on my second 21day pack of Dianette and wasn't sure whether my mood swings and how upset I have been was because of just what's going on in my life right now, or perhaps the pill. But to be honest I'm still not sure, not that I don't believe it can, but because it's just the situation I'm in. We'll have to see. But I don't think it's helped with how I'm feeling that's for sure.