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Glutamatergic Dysfunction in OCD

« H E » email
posted Saturday, 7 October 2006

Primary Psychiatry. 2006;13(10):65-77

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder and the tenth leading cause of disability in the world. The introduction of serotonin reuptake inhibitors (SRIs) in the 1980s represented an important advance in the treatment of OCD. However, most patients show only a partial response to existing treatments and a full remission of OCD symptoms is not frequently observed. Clinical experience and research has highlighted the role of serotonin and dopamine in OCD. The clinical observation that SRIs and augmentation with dopamine antagonists only yields a partial treatment response in most patients suggests that other neurotransmitters contribute to the neurobiology of the illness. Recent research findings raise the possibility that agents that directly reduce glutamate hyperactivity or its consequences in the central nervous system are efficacious as novel therapeutic interventions. This article reviews current treatment strategies for OCD and summarizes the growing body of research implicating glutamatergic dysfunction in OCD.

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© 2006 Primary Psychiatry

tags: obsessive compulsive disorder    glutamate  

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