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Paroxetine (Paxil®, Seroxat®) and risk of suicide in adults

« H E » email
posted Tuesday, 9 May 2006

Paroxetine (Paxil®, Seroxat®) And Risk Of Suicide In Adults

The chairman of the British Commission on Human Medicines has issued a public health alert on paroxetine and the risk of suicidal behavior.

The alert concerns new analyses of paroxetine trials which are to be published by the manufacturer GlaxoSmithKline (GSK), which focus on the risk of suicidal behavior in the adult population, conducted as part of a review by the US FDA.

The new analyses highlight the importance of monitoring all patients treated with SSRIs for worsening of their symptoms or mood changes but do not alter the prescribing advice for SSRIs issued in December 2004 following the review by the CSM Expert Working Group on the Safety of SSRIs.

The new analyses are being evaluated by the Commission on Human Medicines (CHM) and the Medicines and Healthcare products Regulatory Agency (MHRA). Until this has taken place, healthcare professionals are reminded of the previous advice that has been issued:
  • Careful and frequent patient monitoring by healthcare professionals and, where appropriate, other carers, is important in the early stages of treatment with paroxetine, especially if a patient experiences worsening of symptoms or if new symptoms arise after starting treatment.
  • Young adults (18-29 years of age) are at a higher background risk of suicidal behavior than older adults and therefore should be monitored particularly closely.

Comment:  
This alert needs to be kept in perspective. As we've noted previously, the data supporting an increased suicide risk is not as clear cut as sometimes claimed, and at least one study has found psychotherapy treated children were just as prone to suicidal thoughts as those treated with antidepressants. OTOH, there is no doubt that anxiety disorders and depression themselves dramatically increase suicide risk, especially if untreated.

Talk to your doctor if you are concerned. Do NOT stop taking antidepressants 'cold-turkey' They should be weaned off slowly over a period of weeks or months. Ask your doctor for a weaning schedule if you intend to discontinue treatment.

tags:  antidepressant  paxil  suicide  seroxat    paroxetine    

links: digg this    del.icio.us    technorati    reddit




1. Paroxetine hell left...
Monday, 20 November 2006 7:28 pm

www.paxilprogress.org

Visit the above website for all the current and up to date info on the defective and dangerous drug that is Seroxat...


2. Anxiety Insights left...
Tuesday, 21 November 2006 1:29 pm :: https://anxietyinsights.info/

Everyone is entitled to their view, but anti medication sites are all much the same, usually listing the same set of claimed horrendous side effects and dire warning of the consequences for those who are duped into taking them by evil, money grasping doctors. What you rarely find are viable alternatives to the "demon" drug(s).

Do some people have bad reactions to paroxetine? Yes.

Do some people have bad reactions to SSRIs? Yes.

Does that mean they should be banned? No.

For every drug there are a small number who are harmed by them. Antibiotics have saved countless millions of lives, but also killed more than a few. Some 12-15,000 Americans die each year from reactions to aspirin, another 75-100,000 require hospitalization.

There are risks in everything. Just driving to the pharmacy is risky. So is doing nothing. About 15-20% with anxiety disorders or depression will attempt suicide. Sadly, many succeed - and despite the impression media reports often give, very few of them were taking antidepressants at the time. Indeed, very few had any treatment.

For the great majority of anxiety or depression patients antidepressants are the only treatment they can readily access and/or afford. Without an alternative your scaremongering is, at best, a waste of time, and at worst, by scaring off those who need help, may actually cause more suffering than it saves.