LinkBlog
Nobel Laureate Eric Kandel on CBT & the neuroscience of psychiatric disease
What to do about the obsessions part of OCD
The Science of Happiness
Minimizing the risk of Post Traumatic Stress
Chat Board
~ Helen ~
Nice webpage, lovely, cool design.
(Note: anti spam delay set)
blog roll
- Agoraphobia
- Anxiety 2 Calm
-
Anxious Living : An Exploration
into Social Anxiety - Dare to Dream
- Dear Tobacco
-
Dr. Deborah Serani's:
Psychological Perspectives - Finding the Confidence
- GNIF Brain Blogger
- Legacy of War
- Mental Health Minutes
- PTSD Combat
- The Happiness Guy
- The Trouble With Spikol
-
WebMD: Anxiety and
Stress Management
recommended links
-
ABIL: Agoraphobics Building
Independant Lives -
Agoraphobia and Panic
Disorder Foundation -
Anxiety Disorders Association
of America - Anxiety Network Australia
- Anxiety-Panic.Com
- AnxietyZone
- BrainPhysics - OCD
-
Canadian Network for Mood
and Anxiety Treatments -
David Baldwin's
Trauma Information Pages - EMDR Institute, Inc.
- EMDR Network Japan
- Fear of Flying course (free)
- Healthy Minds
- Internet Guide to REBT, CBT
- Living with a Brain Disorder
- Morita Therapy
- Mayo Clinic : Depression
- Mayo Clinic : GAD
- Mayo Clinic : OCD
- Mayo Clinic : Panic Attacks
- Mayo Clinic : PTSD
- Mayo Clinic : Social Anxiety
-
Medicines.org.uk - Anxiety &
Depression guides - Mind-Your-Mind Canada
- National Center for PTSD
-
National Institute of Mental
Health (NIMH) - No Such Thing As Crazy
- OCD Action, UK
- OCD Ireland
- Obsessive Compulsive Foundation
- Open Minds, Open Doors
- Paniccure.com
- Partners With PTSD
-
Rational Emotive Behavior
Therapy (REBT) - Sane Australia
-
Shyness & Social Anxiety
Service of Australia -
Social Phobia/Social Anxiety
Association - Social Anxiety Support board
-
South African Depression &
Anxiety Group - Suicide Prevention Help
-
tAPir - the Anxiety Panic
internet resource -
The Panic Center (Free
CBT based programs)
"just don't smoke"
"Don't smoke, whatever you do, just don't smoke."
Yul Brynner
Yul Brynner
- Menthol cigarettes harder to quit
- Secondhand smoke in cars serious threat to kid's health
- Starting smoking young increases addiction risk
-
Smoking doesn't slim girls;
stunts boys' growth - 40 reasons why you should quit smoking
- Pregnant smokers 'prime' their kids to smoke
- Smoking related coronary artery disease quickly reversed if young smokers quit
- Not ready to quit? Try cutting back
- Half smoking again within year of lung cancer surgery
- Cutting back 'compensation' increases toxin load per cigarette
- Tobacco companies upped nicotine level 11% since 1998
- Workplace passive smoke increases lung cancer risk
- Hooked by genes: The DNA sequences cigarette companies love
- Smoking causes long lasting changes to brain's bio chemistry
- Nicotine receptor stimulant trebles the odds of stopping smoking
- Bupropion, nortriptyline double chances of quitting
- Nicotine's powerful role in reinforcing smoking
- Pregnant smokers raise child's risk of stroke, heart attack
- Smoking linked to pancreatic cancer
anti torture campaign
- Torture experts write APA policy
- [APA] still rocked by torture debate
- Petition for psychologists
- AMA president says APA "did not accurately represent our ethical guidelines"
- Psychologists Aiding Torturers
-
Annual conference endorses
APA's torture policy :( - Physicians for Human Rights call on Congress to vote No on Military Commissions Bill
-
Torture is a Form of Trauma;
Trauma Causes PTSD - Psychoanalysts' association condemns torture use
- Humiliating, inhumane or degrading treatment IS torture
Deputy Army Chief of Staff for Intelligence, Lt. General John (Jeff) Kimmons, has stated that no actionable intelligence had been obtained through abusive interrogation methods in the last 5 years.
monument, Monmouth County
New Jersey.
Researchers shed light on anxiety and alcohol intake
posted Tuesday, 4 October 2005
Researchers Shed Light on Anxiety and Alcohol Intake
Scientists have identified a brain mechanism in rats that may play a central role in regulating anxiety and alcohol-drinking. The finding, by researchers supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), could provide important clues about the neurobiology of alcohol-drinking behaviors in humans. A report of the study appears in the October 3, 2005 issue of the Journal of Clinical Investigation."This is an intriguing finding," notes NIAAA Director Ting-Kai Li, M.D. "These experiments, conducted in rats selectively bred to have a high affinity for alcohol, help us address questions about the potential role that anxiety might play in human alcoholism. These molecular studies also may reveal potential targets for therapy of anxiety and alcoholism."
Researchers led by Subhash C. Pandey, Ph.D., Associate Professor and director of neuroscience alcoholism research in the Department of Psychiatry at the University of Illinois at Chicago (UIC) and Jesse Brown VA Medical Center in Chicago, found that "P" rats, a strain bred to prefer alcohol, showed more anxiety-like behaviors and drank more alcohol, than non alcohol-preferring "NP" rats.
Some researchers have suggested that high levels of anxiety may predispose some individuals to becoming alcoholic. "Genetically high anxiety levels are important in the promotion of higher alcohol consumption in humans," said Pandey. "Drinking is a way for these individuals to self-medicate."
Dr. Pandey and his colleagues also found that levels of CREB, a protein involved in a variety of brain functions, were lower in certain brain areas of P rats compared with NP rats. Levels of neuropeptide Y (NPY), a molecule that regulates the function of several neurotransmitters and is known to play a role in anxiety and alcohol-drinking behaviors, also were lower in P rats. One function of CREB is to regulate the production of NPY.
"Compared to NP rats, levels of CREB and NPY were innately lower in the central amygdala and medial amygdala of P rats," explains Dr. Pandey, "brain areas which play a crucial role in anxiety behaviors and which have been shown previously to be involved in rewarding, reinforcing, and motivational aspects of alcohol drinking behaviors. And turning off CREB function in the central amygdala of NP rats makes them look like P rats - more anxious and thus more likely to drink."
Alcohol intake reduced anxiety-like behaviors in the P rats, an effect that was associated with increased CREB function and NPY production in the central and medial amygdala. And by administering compounds that promote CREB function and NPY production in the central amygdala, researchers were able to reduce anxiety - and alcohol intake - in P rats. On the other hand, by disrupting CREB function (and the concomitant NPY production) in the central amygdala of NP rats, the researchers were able to provoke anxiety-like behavior and promote alcohol intake in those animals.
Dr. Pandey and his colleagues proposed that decreased CREB-dependent NPY production in the central amygdala might be a pre-existing condition for anxiety and alcohol-drinking behaviors.
"Our findings implicate this pathway in genetic predisposition to high anxiety and alcohol-drinking behaviors of P rats," says Dr. Pandey. "Future studies should explore the relationship of other CREB-related compounds to these phenomena in P rats or other animal models."
Sources: NIAAA | UIC
Full study text... (
, 1.98MB)Related paper:
The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism (
comments
Entry Trackback
There have been 0 trackback items to this entry.
Trackback URL or click to read:
https://anxietyinsights.info/read/trackback/1499431.htm