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Antidepressants prove addictive to some

When Gina O'Brien decided she no longer needed drugs to quell her anxiety and panic attacks, she followed doctor's orders by slowly tapering her dose of the antidepressant Paxil. The gradual withdrawal was supposed to prevent unpleasant symptoms that can result from stopping antidepressants cold turkey. But it didn't work.

"I felt so sick that I couldn't get off my couch," O'Brien said. "I couldn't stop crying."

Overwhelmed by nausea and uncontrollable crying, she felt she had no choice but to start taking the pills again. More than a year later the Michigan woman still takes Paxil, and expects to be on it for the rest of her life.

In the almost two decades since Prozac - the first of the antidepressants known as SRIs, or serotonin reuptake inhibitors - hit the market, a number of patients have reported extreme reactions to discontinuing the drugs. Two of the best-selling antidepressants - Effexor and Paxil - have led to so many complaints that some doctors avoid prescribing them altogether.


Comment:  
Antidepressants are not 'addictive' in the same way heroin is, but unpleasant withdrawal effects can act as a negative reinforcement to quitting in the same way withdrawal headaches do when some people stop taking aspirin after a prolonged period of use.

As this article notes, some antidepressants are more likely to produce these unpleasant effects than others. Due to its long half-life fluoxetine (Prozac®) withdrawal effects are uncommon. Switching to this SSRI and then tapering may be a better option than trying to do so directly from short acting drugs like paroxetine (Paxil®).


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