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JournalNews
Reuters:
ECT effective but underused for severe Depression
Fairfield Echo
Challenges in diagnosing and treating maternal depression
(also at: )
Bullied mice cast doubt on 'chemical imbalance' theory.
Does a deficiency of the monoamines serotonin, norepinephrine, and dopamine cause depression? New evidence from the University of Texas Southwest Medical Center challenges this popular "chemical imbalance" theory, suggesting that altered DNA molecules or DNA scarring may be the real culprit.
Researchers studied how mice respond to chronic defeat to investigate the molecular mechanisms behind depression.
The investigators exposed groups of mice to a different aggressor mouse daily for 10 days. These exposed mice-called defeated mice-later avoided social contact with unfamiliar mice. This reaction to social defeat was similar to that of humans with depression and anxiety disorders such as posttraumatic stress disorder (PTSD). A 30-day regimen of imipramine or fluoxetine reversed the defeated mice's symptoms.
Current Psychiatry ©2006 Dowden Health Media
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tags: bdnf dopamine serotonin norepinephrine
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