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Insomnia: Predisposition, Precipitation, Perpetuation

A State of Mind - A special report for the Canadian Mental Health Association (pdf)

The Right Patients for the Drug: Managing the Placebo Effect in Antidepressant Trials (pdf)

On Target Spring 2007 newsletter - a anxiety & depression resource (PDF)

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Damaged DNA: Depression's hidden culprit?

« H E » email
posted Sunday, 2 July 2006

Bullied mice cast doubt on 'chemical imbalance' theory.

Does a deficiency of the monoamines serotonin, norepinephrine, and dopamine cause depression? New evidence from the University of Texas Southwest Medical Center challenges this popular "chemical imbalance" theory, suggesting that altered DNA molecules or DNA scarring may be the real culprit.

Researchers studied how mice respond to chronic defeat to investigate the molecular mechanisms behind depression.

The investigators exposed groups of mice to a different aggressor mouse daily for 10 days. These exposed mice-called defeated mice-later avoided social contact with unfamiliar mice. This reaction to social defeat was similar to that of humans with depression and anxiety disorders such as posttraumatic stress disorder (PTSD). A 30-day regimen of imipramine or fluoxetine reversed the defeated mice's symptoms.

  Current Psychiatry ©2006 Dowden Health Media

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