LinkBlog
Insomnia: Predisposition, Precipitation, Perpetuation
A State of Mind - A special report for the Canadian Mental Health Association (pdf)
The Right Patients for the Drug: Managing the Placebo Effect in Antidepressant Trials (pdf)
On Target Spring 2007 newsletter - a anxiety & depression resource (PDF)
blog roll
- Agoraphobia
- Anxiety 2 Calm
-
Anxious Living : An Exploration
into Social Anxiety - Dare to Dream
- Dear Tobacco
-
Dr. Deborah Serani's:
Psychological Perspectives - Fast Weight Loss?
- Finding the Confidence
- GNIF Brain Blogger
- Legacy of War
- Mental Health Minutes
- PTSD Combat
- The Happiness Guy
- The Trouble With Spikol
-
WebMD: Anxiety and
Stress Management - We Worry: A Blog for the Anxious
recommended links
Depression Is Real Coalition
-
ABIL: Agoraphobics Building
Independant Lives -
Agoraphobia and Panic
Disorder Foundation -
Anxiety Disorders Association
of America - Anxiety Network Australia
- Anxiety-Panic.Com
- AnxietyZone
- Army Behavioral Health
- BrainPhysics - OCD
-
Canadian Network for Mood
and Anxiety Treatments - Choices in Mental Health (UK)
-
David Baldwin's
Trauma Information Pages - EMDR Institute, Inc.
- EMDR Network Japan
- Fear of Flying course (free)
- Healthy Minds
- Information for People with Anxiety Disorders
- Internet Guide to REBT, CBT
- Living with a Brain Disorder
- Morita Therapy
- Mayo Clinic : Depression
- Mayo Clinic : GAD
- Mayo Clinic : OCD
- Mayo Clinic : Panic Attacks
- Mayo Clinic : PTSD
- Mayo Clinic : Social Anxiety
-
Medicines.org.uk - Anxiety &
Depression guides - Mind-Your-Mind Canada
- National Center for PTSD
-
National Institute of Mental
Health (NIMH) - No Such Thing As Crazy
- OCD Action, UK
- OCD Ireland
- Obsessive Compulsive Foundation
- Open Minds, Open Doors
- Paniccure.com
- Partners With PTSD
-
Rational Emotive Behavior
Therapy (REBT) - Sane Australia
-
Shyness & Social Anxiety
Service of Australia -
Social Phobia/Social Anxiety
Association - Social Anxiety Support board
-
South African Depression &
Anxiety Group - Suicide Prevention Help
-
tAPir - the Anxiety Panic
internet resource -
The Panic Center (Free
CBT based programs) - The School of OCD
- UN-WHO Drug Trials Database
"just don't smoke"
Yul Brynner
- Menthol cigarettes harder to quit
- Secondhand smoke in cars serious threat to kid's health
- Starting smoking young increases addiction risk
-
Smoking doesn't slim girls;
stunts boys' growth - 40 reasons why you should quit smoking
- Pregnant smokers 'prime' their kids to smoke
- Smoking related coronary artery disease quickly reversed if young smokers quit
- Not ready to quit? Try cutting back
- Half smoking again within year of lung cancer surgery
- Cutting back 'compensation' increases toxin load per cigarette
- Tobacco companies upped nicotine level 11% since 1998
- Workplace passive smoke increases lung cancer risk
- Hooked by genes: The DNA sequences cigarette companies love
- Smoking causes long lasting changes to brain's bio chemistry
- Nicotine receptor stimulant trebles the odds of stopping smoking
- Bupropion, nortriptyline double chances of quitting
- Nicotine's powerful role in reinforcing smoking
- Pregnant smokers raise child's risk of stroke, heart attack
- Smoking linked to pancreatic cancer
- Neurobiology of Smokers' Cravings
- 'Low cancer risk' cigarettes as deadly as regular kind
- Quitting reduces lung cancer death risk by 70%
- Fetal nicotine exposure linked to teen attention problems
- Outdoor second-hand smoke exposure can harm
- Response to day's first cigarette predicts ease of quitting
anti torture campaign
- Torture experts write APA policy
- [APA] still rocked by torture debate
- Petition for psychologists
- AMA president says APA "did not accurately represent our ethical guidelines"
- Psychologists Aiding Torturers
-
Annual conference endorses
APA's torture policy :( - Physicians for Human Rights call on Congress to vote No on Military Commissions Bill
-
Torture is a Form of Trauma;
Trauma Causes PTSD - Psychoanalysts' association condemns torture use
- Humiliating, inhumane or degrading treatment IS torture
Deputy Army Chief of Staff for Intelligence, Lt. General John (Jeff) Kimmons, has stated that no actionable intelligence had been obtained through abusive interrogation methods in the last 5 years.
monument, Monmouth County
New Jersey.
Abstract: Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050
Eur J Pharmacol. 2006 Oct 17; [Epub ahead of print]
Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.
Shaw AM, Boules M, Zhang Y, Williams K, Robinson J, Carlier PR, Richelson E.
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Most currently prescribed antidepressants act by selectively increasing the synaptic availability of serotonin or norepinephrine, or through action on both serotonin and norepinephrine. However, most therapies require several weeks of treatment before improvement of symptoms is observed and not all patients respond to antidepressant treatment.
One strategy that has emerged in new antidepressant development is the use of triple reuptake inhibitors, which inhibit reuptake of serotonin, norepinephrine, and dopamine. These compounds have been hypothesized to have a more rapid onset of activity and better efficacy over single or dual reuptake inhibitor antidepressants in part due to the addition of the dopamine component.
We have developed novel compounds that are analogs of venlafaxine, of which two, racemic PRC025 ((2SR, 3RS)-N,N-dimethyl-3-cyclohexyl-3-hydroxy-2-(2'-naphthyl)propylamine) and PRC050 ((2RS,3RS)-N-methyl-3-hydroxy-2-(2'-naphthyl)-3-phenylpropylamine), are highly potent at human serotonin, norepinephrine, and dopamine transporters and inhibit the reuptake of serotonin, norepinephrine, and dopamine into rat brain synaptosomes.
These compounds were tested in animal models used to evaluate potential antidepressants: the forced swim test in rats and the tail suspension test in mice. In the forced swim test, both PRC025 and PRC050 reduced the time spent immobile and increased the time spent swimming, comparable to the effects seen with imipramine, a tricyclic antidepressant. In addition, both PRC025 and PRC050 were effective in reducing the time spent immobile in the tail suspension test, again with effects comparable to imipramine.
Therefore it appears that our compounds may possess antidepressant activity and represent a new class of triple reuptake inhibitors.
PMID: 17109850 [PubMed - as supplied by publisher]
(Text has been reformatted for clarity; ed.)