Calendar

«« Jan 2008 »»
S M T W T F S
    1 2 3 4 5
6 7 8 9 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31

Search Box


HealthCentral Top Site Award

IBS Tales Hope Award

LinkBlog

'Managing Holiday Stress' a LifeCare® guide (PDF)

Generalized Anxiety Disorder - Patient treatment manual (pdf)

Understanding post-traumatic stress disorder

  More

Contact

Mailing List

RSS Feeds








Translation

Disclaimer

All content within Anxiety Insights is provided for general information only, and should not be treated as a substitute for the medical advice of your doctor or other health care professional.

Anxiety Insights is not responsible or liable for any diagnosis made by a reader based on the content of this website.

Anxiety Insights is not liable for the contents of any external internet sites listed, nor does it endorse any commercial product or service mentioned or advised on any of the sites.

Always consult your doctor if you are in any way concerned about your health.

recommended links

Depression is Real's Down & Up Show
      Weekly audio-casts from the
      Depression Is Real Coalition

we support

Kiva.org - micro loans that change lives

Moving a Nation to Care : Post Traumatic Stress Disorder and America's Returning Troops, by Ilona Meagher

No Longer Lonely.com

"just don't smoke"


"Don't smoke, whatever you do, just don't smoke."
                        Yul Brynner

Hit Counter

Total: 1,105,806
since: 14 May 2006

Admin console

Log-In

My Blog    My Profile

Leave Message

Add as neighbors






Blogion.com

Blog Flux Directory



Blogarama - The Blogs Directory

blog search directory

BlogTagstic - Blog Directory

Find Blogs in the Blog Directory



LS Blogs

Top Health Sites





Health Blogs - Blog Top Sites

Webloogle Blog Directory

Bloggapedia - Find It!

Smoking linked to pancreatic cancer


Pic: University of Cincinnati

Researchers at Michigan State University have added yet another piece to the puzzle that links cigarette smoking with cancer of the pancreas, one of the deadliest forms of cancer.

In research published in the recent issue of the International Journal of Cancer, MSU's James Trosko and colleagues zeroed in on the mechanism by which a healthy cell turns cancerous.

Specifically, they found that the chemicals produced by the burning of tobacco products - polycyclic aromatic hydrocarbons, or PAHs - interfere with communication between the body's cells. More importantly, the work showed that some of these chemicals don't necessarily initiate the cancer, but rather contribute to the promotion of it.

"These PAH chemicals are related to the multistage, multimechanism process of carcinogenesis, not by mutating the stem cell, but by triggering the stem cell that's been previously mutated to proliferate," said Trosko, a professor of pediatrics and human development. "This finding has major implications, including the possibility that dietary intervention might interrupt or even reverse the promotion of pancreatic cancers."

Until now, most scientists thought that specific PAHs produced by burning tobacco mutated genes which, in turn, triggered the cancer mechanism.

"We take issue with this interpretation," Trosko said. "We don't believe that the PAH chemicals cause mutations which then lead to cancer."

Pancreatic cancer is one of the more deadly forms of cancer, with an average survival rate of only about a year. It's projected that more than 37,000 Americans will be diagnosed with pancreatic cancer in 2007.

Trosko noted that PAHs are formed when any substance containing certain proteins is burned, including foods.

"PAHs are all over," he said. "When you grill a steak or a hamburger, for example, you get exactly the same class of chemicals."

This research is the culmination of nearly 30 years of work in Trosko's lab. It was in 1979 that Trosko, colleagues and students demonstrated that tumor-promoting chemicals interfered with a cell's ability to communicate with other cells. Later, this group isolated adult human pancreatic stem cells from human pancreatic tissue.

Subsequent published findings indicated that these stem cells appeared to be targets for cancer.

"Since we had the system here in our lab, we decided to see if PAHs would act as a tumor promoter," he said. "And sure enough they did."

The good news is that people who quit smoking can dramatically improve their chances of avoiding cancers.

"If these chemicals act like cancer promoters and not initiators," Trosko said, "then quitting smoking can assist in interrupting the process."


Tai MH, Upham BL, Olson LK, Tsao MS, Reed DN Jr, Trosko JE.
Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells.
Int J Cancer. 2007 Jan 31;120(9):1855-1862   [Abstract]