sponsored by


Endsleigh offer competitive
Life Insurance policies

Calendar

«« Aug 2007 »»
S M T W T F S
     
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28 29 30 31

Search Box


HealthCentral Top Site Award

IBS Tales Hope Award

LinkBlog

6 Golden Rules for Conquering Performance Anxiety by David Leisner

Freedom from Fear's On Target Summer/Fall 2007 newsletter - an anxiety & depression resource (PDF)

Switching between monoamine oxidase inhibitors (MAOIs) and SSRI or tricyclic antidepressants (.doc format)

Switching between tricyclic, SSRI and related antidepressants (.doc format)

  More

Contact

Mailing List

RSS Feeds








Translation

Disclaimer

All content within Anxiety Insights is provided for general information only, and should not be treated as a substitute for the medical advice of your doctor or other health care professional.

Anxiety Insights is not responsible or liable for any diagnosis made by a reader based on the content of this website.

Anxiety Insights is not liable for the contents of any external internet sites listed, nor does it endorse any commercial product or service mentioned or advised on any of the sites.

Always consult your doctor if you are in any way concerned about your health.

recommended links

Depression is Real's Down & Up Show
      Weekly audio-casts from the
      Depression Is Real Coalition


No Longer Lonely.com

"just don't smoke"


"Don't smoke, whatever you do, just don't smoke."
                        Yul Brynner

Hit Counter

Total: 831,087
since: 14 May 2006

Admin console

Log-In

My Blog    My Profile

Leave Message

Add as neighbors






Blogion.com

Blog Flux Directory



Blogarama - The Blogs Directory

blog search directory

BlogTagstic - Blog Directory

Find Blogs in the Blog Directory



LS Blogs

Top Health Sites





Health Blogs - Blog Top Sites

Bloggapedia - Find It!

Effectiveness of VNS therapy for treatment-resistant depression confirmed

« H E » email
posted Tuesday, 21 August 2007

A study, led by Ziad Nahas, M.D., associate professor, Medical University of South Carolina (MUSC) Department of Psychiatry has found that Vagus Nerve Stimulator Therapy (VNS) modulates areas of the brain that control mood. The researchers also identified variables, such as length of use, strength of stimulation and level of depression, to better understand the impact of VNS Therapy.

"These data provide further insight into VNS therapy's distinct mechanism of action and support its previously demonstrated long-term, sustained efficacy," Nahas said. "We are encouraged to see the unique benefit VNS therapy may bring to patients with one of the most difficult-to-treat forms of depression and are excited to continue neurostimulation research at MUSC."

The study demonstrated that VNS Therapy modifies activity of the medial prefrontal cortex, the same brain area targeted by antidepressants and electroconvulsive therapy (ECT).

A critical time for such effective modulation occurs approximately at 30 weeks of treatment. The modulation could support VNS Therapy's unique mechanism of action as a long-term treatment for chronic or recurrent depression and directly corresponds with the timeframe in which patients typically experience a decrease in symptoms. Further analysis of the data demonstrates that modulation of the brain is a dynamic process that over time leads to indirectly related improved response with continued use.

These findings corroborate an earlier MUSC-led study that revealed approximately two-thirds of patients who respond to VNS Therapy continue to experience significant clinical benefit at 24 months, making VNS Therapy the only treatment for treatment-resistant depression to show such a long-term improvement.

The FDA approved VNS therapy in 2005 as an adjunctive long-term treatment of chronic or recurrent depression for patients (18 years of age or older) who are experiencing a major depressive episode and have not had an adequate response to four or more antidepressant treatments. It is the only device approved for treatment-resistant depression. VNS therapy is delivered from a small pacemaker-like device implanted in the chest area that sends mild pulses to the brain via the vagus nerve in the neck.

Related articles...


Nahas Z, Teneback C, Chae JH, Mu Q, et al. Serial Vagus Nerve Stimulation Functional MRI in Treatment-Resistant Depression Neuropsychopharmacology 2007 Aug;32(8):1649-60   [Abstract]

tags: clinical depression  treatment resistant depression  vagus nerve stimulation  

links: digg this    del.icio.us    technorati    reddit