sponsored by


Endsleigh offer competitive
Life Insurance policies

Calendar

«« Sep 2007 »»
S M T W T F S
           
1
2
3
4
5 6 7 8
9 10 11 12 13 14 15
16 17 18 19 20 21 22
23 24 25 26 27 28 29
30

Search Box


HealthCentral Top Site Award

IBS Tales Hope Award

LinkBlog

Crying Shame - a Priory Group survey about stigma and mental illness in Britain (pdf)

6 Golden Rules for Conquering Performance Anxiety by David Leisner

Freedom from Fear's On Target Summer/Fall 2007 newsletter - an anxiety & depression resource (PDF)

Switching between monoamine oxidase inhibitors (MAOIs) and SSRI or tricyclic antidepressants (.doc format)

  More

Contact

Mailing List

RSS Feeds








Translation

Disclaimer

All content within Anxiety Insights is provided for general information only, and should not be treated as a substitute for the medical advice of your doctor or other health care professional.

Anxiety Insights is not responsible or liable for any diagnosis made by a reader based on the content of this website.

Anxiety Insights is not liable for the contents of any external internet sites listed, nor does it endorse any commercial product or service mentioned or advised on any of the sites.

Always consult your doctor if you are in any way concerned about your health.

recommended links

Depression is Real's Down & Up Show
      Weekly audio-casts from the
      Depression Is Real Coalition


No Longer Lonely.com

"just don't smoke"


"Don't smoke, whatever you do, just don't smoke."
                        Yul Brynner

Hit Counter

Total: 842,745
since: 14 May 2006

Admin console

Log-In

My Blog    My Profile

Leave Message

Add as neighbors






Blogion.com

Blog Flux Directory



Blogarama - The Blogs Directory

blog search directory

BlogTagstic - Blog Directory

Find Blogs in the Blog Directory



LS Blogs

Top Health Sites





Health Blogs - Blog Top Sites

Bloggapedia - Find It!

Parkinson's related depression often unresponsive to antidepressants

« H E » ZFZ :: email
posted Wednesday, 29 August 2007

Preliminary results of the pan-European PRODEST (Profile of Depression Symptoms in PD patients) study in 1,016 patients with Parkinson`s disease (PD) were presented at the 11th Congress of the European Federation of Neurological Societies (EFNS) in Brussels this week, revealing unique features of PD-related depression and its treatment.

The study confirmed that depressive symptoms associated with PD are not only highly prevalent, but nearly half (44.1%) of patients receiving antidepressant treatment (n=211) continued to experience depressive symptoms.

"These symptoms have a significant impact on PD patients' quality of life, often equal in impact to that of the traditionally better known motor symptoms of Parkinson's disease. The results suggest that many depressive symptoms are expression of Parkinson`s disease, rather than of a depressive syndrome. This consideration, if supported by further analysis of the PRODEST study results, might suggest different treatment approaches of depression in PD," said Professor Paolo Barone, Department of Neurological Sciences, University of Napoli-Federico II, Naples, Italy, and lead investigator of PRODEST.

In those 282 patients with a reported medical history of depression, the study results also showed that over half (54.3 percent) of these patients had a marked score in DSM IV item 1 or 2), with 66 percent (n=186) receiving anti-depressant treatment, confirming a persistence of depressive symptoms despite treatment.

Data from recent studies with pramipexole, a non-ergot dopamine agonist, have shown a beneficial effect on the depressive and motivational symptoms in Parkinson's disease. Ongoing trials are aimed to confirm these previous findings and continue to investigate this aspect of pramipexole's clinical profile in more detail.

Commenting on the role of pramipexole, Professor Matthias Lemke, M.D., Professor of Psychiatry and Medical Director at the Rheinische Kliniken, Bonn, Germany, said: "PD-related depressive symptoms can overlap or even be mistaken for motor symptoms. It is therefore important that physicians learn to differentiate these in order to find the optimal treatment for their PD patients. While pramipexole has proven an effective treatment for the motor symptoms of PD, there is now evidence that pramipexole may also improve PD-related depressive symptoms."

PD-related depressive symptoms have also been studied in an ongoing two year Italian study, known as PRIAMO. Initial findings of the 55 center study support the evidence that non-motor symptoms (NMS) are highly prevalent with the majority of patients experiencing one or more non-motor symptoms. Psychiatric symptoms (anxiety and depression) were rated most frequently and with a high impact on patients' quality of life.

"The conclusions from PRIAMO further support the PRODEST study in highlighting the need to address the often undiagnosed and under-treated aspects of Parkinson's disease which impart a significant burden on PD patients, relative to their disease severity," said Professor Barone, member of the Steering Committee of the PRIAMO Study Group.

PRODEST is a multi-national, multicentre, prospective observational study in which 24 centers in eight European countries participated with 1016 patients with idiopathic Parkinson's Disease and a score on the Mini Mental State Examination (MMSE) of > 24. The study population was evenly divided (51.7%:48.3%) early vs. advanced PD.


Barone P, Goetz CG, Houben JJ, et al. PRODEST - Depressive Symptoms In Parkinson's Disease: Demographic Data Presentation P1122, 11th Congress of the Federation of Neurological Societies 2007 Aug 26.

tags: clinical depression  parkinsons disease  

links: digg this    del.icio.us    technorati    reddit